compartir en google+ compartir en facebook Compartir en Twitter compartir en Linkedin

Área de Investigación

Registro SEMI-COVID-19

La Sociedad Española de Medicina Interna (SEMI) ha desarrollado un registro online que incluye un número extenso de parámetros epidemiológicos, clínicos, de tratamiento, de laboratorio y radiográficos, que se obtendrán de las historias clínicas electrónicas de los pacientes hospitalizados con infección por SARS-CoV-2 confirmada por laboratorio de los hospitales españoles. El estudio ha sido clasificado como observacional no-EPA por la AEMPS y ha sido autorizado por el CEI Provincial de Málaga. La aplicación del registro está en: https://covid.reginus.es

A fecha 22 de abril de 2021, gracias a la colaboración de más de 700 investigadores de la Sociedad Española de Medicina Interna, se han incluido en el Registro más de 22.000 pacientes.

Publicaciones derivadas del Registro hasta el momento:

  1. Olalla-Sierra J, Martín-Escalante MD, García-Alegría J, Rubio-Rivas M, de Miguelcampo B, Zurita-Etayo M, Arbones-Fernández L, Alcalá-Pedrajas JN, Roldán-Silvestre A, Cortés-Rodríguez B, Casas-Rojo JM, Núñez-Cortés JM, on behalf of the SEMI-COVID-19 Network. Covid-19 hospitalization outcomes in persons with and without HIV in SPAIN: the Semi-Covid-19 registry. AIDS: August 20, 2021 - Volume - Issue - doi: 10.1097/QAD.0000000000003056
  2. Díaz-Simón R, Lalueza A, Lora-Tamayo J, Rubio-Rivas M, Mendo CL, Martínez MLT, Méndez CA, Pesqueira Fontán PM, Cruz AF, Cabrera JLR, Rodríguez BC, Rubio AE, de Ávila VSR, García GMG, Osorio LC, González-Fernández M, Noya AG, Wittel MB, Fernandez FA, Sempere VM, Artero A, Loureiro-Amigo J, Huelgas RG, Santos JMA, Lumbreras C. Clinical Characteristics and Risk Factors of Respiratory Failure in a Cohort of Young Patients Requiring Hospital Admission with SARS-CoV2 Infection in Spain: Results of the Multicenter SEMI-COVID-19 Registry. J Gen Intern Med 2021;1–8. DOI: 10.1007/s11606-021-07066-z
  3. Salinas-Botrán A, Sanz-Cánovas J, Pérez-Somarriba J, Pérez-Belmonte LM, Cobos-Palacios L, Rubio-Rivas M, de Cossío Tejido S, Manuel Ramos-Rincón J, Méndez-Bailón M, Gómez-Huelgas R. [Clinical characteristics and risk factors for mortality upon admission in patients with heart failure hospitalized due to COVID-19 in Spain]. Rev Clin Esp 2021. DOI: 10.1016/j.rce.2021.06.004
  4. Suárez-García I, Perales-Fraile I, González-García A, Muñoz-Blanco A, Manzano L, Fabregate M, Díez-Manglano J, Aizpuru EF, Fernández FA, García AG, Gómez-Huelgas R, Ramos-Rincón J-M. In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain. PLoS One 2021;16(8):e0255524. DOI: 10.1371/journal.pone.0255524
  5. García-Cervera C, Giner-Galvañ V, Wikman-Jorgensen P, Laureiro J, Rubio-Rivas M, Gurjian Arena A, Arnalich-Fernandez F, Beato Pérez JL, Vargas Núñez JA, González Igual JJ, Díez-Manglano J, Méndez Bailón M, García Blanco MJ, Freire Castro SJ, Aranda Lobo J, Manzano L, Magallanes Gamboa JO, Arribas Pérez L, González Moraleja J, Calderón Hernaiz R, García Alegría J, González Noya A, Gómez Huelgas R, Lumbreras Bermejo C, Antón Santos JM. Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry. J Gen Intern Med 2021;1–9. DOI: 10.1007/s11606-021-07017-8
  6. Martinez-Lacalzada M, Viteri-Noël A, Manzano L, Fabregate M, Rubio-Rivas M, Garcia SL, Fernández FA, Beato Pérez JL, Vargas Núñez JA, Manuel EC, Espiño Álvarez AC, Freire Castro SJ, Loureiro-Amigo J, Pesqueira Fontan PM, Pina A, Álvarez Suárez AM, Asiain AS, López BG, Luque del Pino J, Cánovas JS, Pérez PC, García García GM, Núñez-Cortés JM, Casas Rojo JM, Huelgas RG, for the SEMI-COVID-19 Network. Predicting critical illness on initial diagnosis of COVID-19 based on easily-obtained clinical variables: development and validation of the PRIORITY model. Clinical Microbiology and Infection. DOI: https://doi.org/10.1016/j.cmi.2021.07.006.
  7. Ramos-Martínez A, Parra-Ramírez LM, Morrás I, Carnevali M, Jiménez-Ibañez L, Rubio-Rivas M, Arnalich F, Beato JL, Monge D, Asín U, Suárez C, Freire SJ, Méndez-Bailón M, Perales I, Loureiro-Amigo J, Gómez-Belda AB, Pesqueira PM, Gómez-Huelgas R, Mella C, Díez-García LF, Fernández-Sola J, González-Ferrer R, Aroza M, Antón-Santos JM, Bermejo CL. Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients. Sci Rep. 2021 Jul 2;11(1):13733. doi: 10.1038/s41598-021-93076-0. PMID: 34215803.
  8. Ena J, Vicente Segura-Heras J, Fonseca-Aizpuru EM, López-Reboiro ML, Gracia-Gutiérrez A, Ángel Martín-Oterino J, Diez-Canseco AM, Pérez-García C, Manuel Ramos-Rincón J, Gómez-Huelgas R; en nombre del grupo de trabajo SEMI-COVID-19. Derivación y validación de una puntuación de riesgo de ingreso en la unidad de cuidados intensivos para pacientes con COVID-19 [Derivation and validation of a risk score for admission to the intensive care unit in patients with COVID-19]. Rev Clin Esp. 2021 Jun 23. Spanish. doi: https://doi.org/10.1016/j.rce.2021.06.003. Epub ahead of print. PMID: 34176952; PMCID: PMC8221018.
  9. Roy-Vallejo E, Sánchez Purificación A, Torres Peña JD, Sánchez Moreno B, Arnalich F, García Blanco MJ, López Miranda J, Romero-Cabrera JL, Herrero Gil CR, Bascunana J, Rubio-Rivas M, Pintos Otero S, Martínez Sempere V, Ballano Rodríguez-Solís J, Gil Sánchez R, Luque del Pino J, González Noya A, Navas-Alcántara MS, Cortés Rodríguez B, Alcalá JN, Suárez-Lombraña A, Andrés Soler J, Gómez-Huelgas R, Casas-Rojo JM, Millán Núñez-Cortés J, on behalf of the SEMI‐COVID‐19 Network on. Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19. Journal of Clinical Medicine [Internet] 2021;10(12). Available from: https://www.mdpi.com/2077-0383/10/12/2642
  10. Loureiro-Amigo J, Suárez-Carantoña C, Oriol-Bermúdez I, Sánchez-Díaz C, Coloma-Conde A, Manzano-Espinosa L, Rubio-Rivas M, Otero-Perpiñá B, Jenaro MMF-M, Coduras-Erdozain A, Garcia-Klepzig JL, Vargas-Parra D, Pesqueira-Fontán PM, Fiteni-Mera I, García-García GM, Jiménez-Torres J, Rodríguez-Cortés P, Costo-Muriel C, Arnalich-Fernández F, Artero A, Carrasco-Sánchez FJ, Escobar-Sevilla J, Alcalá-Pedrajas JN, Gómez-Huelgas R, Ramos-Rincón J-M. Prone Position in COVID-19 Patients With Severe Acute Respiratory Distress Syndrome Receiving Conventional Oxygen Therapy: A Retrospective Study. Archivos de Bronconeumología 2021; DOI: 10.1016/j.arbres.2021.05.018
  11. Rubio-Rivas, M.; Corbella, X.; Formiga, F.; Menéndez Fernández, E.; Martín Escalante, M.D.; Baños Fernández, I.; Arnalich Fernández, F.; Del Corral-Beamonte, E.; Lalueza, A.; Parra Virto, A.; Roy Vallejo, E.; Loureiro-Amigo, J.; Álvarez Suárez, A.M.; Abadía-Otero, J.; Navarro De La Chica, M.; Estévez González, R.; Hernández Milián, A.; Areses Manrique, M.; Blázquez Encinar, J.C.; González Noya, A.; González Ferrer, R.; Pérez Aguilera, M.; Gil Sánchez, R.; Millán Núñez-Cortés, J.; Casas-Rojo, J.M.; on behalf of, t.S.-C.-1.N. Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry. J. Clin. Med. 2021, 10, 2214. DOI: 10.3390/jcm10102214
  12. Martos Pérez F, Gomez Huelgas R, Martín Escalante MD, Casas Rojo JM. Minimizing Selection and Classification Biases. Comment on "Clinical Characteristics and Prognostic Factors for Intensive Care Unit Admission of Patients With COVID-19: Retrospective Study Using Machine Learning and Natural Language Processing". J Med Internet Res. 2021 May 13. doi: https://doi.org/10.2196/27142. Epub ahead of print. PMID: 33989163.
  13. Calderón-Parra J, Muiño-Miguez A, Bendala-Estrada AD, Ramos-Martínez A, Muñez-Rubio E, Fernández Carracedo E, Tejada Montes J, Rubio-Rivas M, Arnalich-Fernandez F, Beato Pérez JL, García Bruñén JM, Del Corral Beamonte E, Pesqueira Fontan PM, Carmona MDM, Fernández-Madera Martínez R, González García A, Salazar Mosteiro C, Tuñón de Almeida C, González Moraleja J, Deodati F, Martín Escalante MD, Asensio Tomás ML, Gómez Huelgas R, Casas Rojo JM, Millán Núñez-Cortés J; SEMI-COVID-19 Network. Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID. PLoS One. 2021 May 11;16(5):e0251340. doi: 10.1371/journal.pone.0251340. PMID: 33974637.
  14. Ramos-Rincón JM, Pérez-Belmonte LM, Carrasco-Sánchez FJ, Jansen-Chaparro S, De-Sousa-Baena M, Bueno-Fonseca J, Pérez-Aguilar M, Arévalo-Cañas C, Bacete Cebrian M, Méndez-Bailón M, Fiteni Mera I, González García A, Navarro Romero F, Tuñón de Almeida C, Muñiz Nicolás G, González Noya A, Hernández Milian A, García García GM, Alcalá Pedrajas JN, Herrero García V, Corral-Gudino L, Comas Casanova P, Meijide Míguez H, Casas-Rojo JM, Gómez-Huelgas R, for the SEMI-COVID-19 Network. Cardiometabolic therapy and mortality in very old patients with diabetes hospitalized due to COVID-19. The Journals of Gerontology: Series A [Internet] 2021 [cited 2021 May 5];(glab124). Available from: https://doi.org/10.1093/gerona/glab124
  15. María del Mar Ayala Gutiérrez, Manuel Rubio-Rivas, Carlos Romero Gómez, Abelardo Montero Sáez, Iván Pérez de Pedro,Narcís Homs, Blanca Ayuso García, Carmen Cuenca Carvajal, Francisco Arnalich Fernández, José Luis Beato Pérez,Juan Antonio Vargas Núñez, Laura Letona Giménez, Carmen Suárez Fernández, Manuel Méndez Bailón, Carlota Tuñón de Almeida, Julio González Moraleja, Mayte de Guzmán García-Monge, Cristina Helguera Amezua, María del Pilar Fidalgo Montero, Vicente Giner Galvañ, Ricardo Gil Sánchez, Jorge Collado Sáenz, Ramon Boixeda, José Manuel Ramos Rincón, Ricardo Gómez Huelgas and on behalf of the SEMI-COVID- Network 19. Autoimmune Diseases and COVID-19 as Risk Factors for Poor Outcomes: Data on 13,940 Hospitalized Patients from the Spanish Nationwide SEMI-COVID-19 Registry. Journal of Clinical Medicine [Internet] 2021;10(9). Available from: https://www.mdpi.com/2077-0383/10/9/1844
  16. Torres-Peña JD, Pérez-Belmonte LM, Fuentes-Jiménez F, et al. Prior Treatment with Statins is Associated with Improved Outcomes of Patients with COVID-19: Data from the SEMI-COVID-19 Registry. Drugs [Internet] 2021 [cited 2021 Mar 30];Available from: https://doi.org/10.1007/s40265-021-01498-x
  17. Josa-Laorden C, Crestelo-Vieitez A, García Andreu MDM, Rubio-Rivas M, Sánchez M, Toledo Samaniego N, Arnalich Fernández F, Iguaran Bermudez R, Fonseca Aizpuru EM, Vargas Núñez JA, Pesqueira Fontan PM, Serrano Ballesteros J, Freire Castro SJ, Pestaña Fernández M, Viana García A, Nuñez Rodriguez V, Giner-Galvañ V, Carrasco Sánchez FJ, Hernández Milián A, Cobos-Siles M, Napal Lecumberri JJ, Herrero García V, Pascual Pérez MLR, Millán Núñez-Cortés J, Casas Rojo JM, On Behalf Of The Semi-Covid-Network. Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study. J Clin Med. 2021 Feb 25;10(5):899. doi: 10.3390/jcm10050899. PMID: 33668766.
  18. Díez-Manglano J, Solís-Marquínez MN, Álvarez García A, Alcalá-Rivera N, Maderuelo Riesco I, Gericó Aseguinolaza M, Beato Pérez JL, Méndez Bailón M, Labirua-Iturburu Ruiz AE, García Gómez M, Martínez Cilleros C, Pesqueira Fontan PM, Abella Vázquez L, Blázquez Encinar JC, Boixeda R, Gil Sánchez R, de la Peña Fernández A, Loureiro Amigo J, Escobar Sevilla J, Guzmán Garcia M, Martín Escalante MD, Magallanes Gamboa JO, Martínez González ÁL, Lumbreras Bermejo C, Antón Santos JM; SEMI-COVID-19 Network. Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry. PLoS One. 2021 Feb 19;16(2):e0247422. doi: 10.1371/journal.pone.0247422. PMID: 33606820.
  19. Lora-Tamayo J, Maestro G, Lalueza A, et al. Early Lopinavir/ritonavir does not reduce mortality in COVID-19 patients: results of a large multicenter study. Journal of Infection 2021 [cited 2021 Feb 14];0(0). DOI: https://doi.org/10.1016/j.jinf.2021.02.011
  20. Artero A, Madrazo M, Fernández-Garcés M, et al. Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study. J Gen Intern Med 2021;Available from: https://doi.org/10.1007/s11606-021-06626-7
  21. Mateos González, M.; Sierra Gonzalo, E.; Casado Lopez, I.; Arnalich Fernández, F.; Beato Pérez, J.L.; Monge Monge, D.; Vargas Núñez, J.A.; García Fenoll, R.; Suárez Fernández, C.; Freire Castro, S.J.; Mendez Bailon, M.; Perales Fraile, I.; Madrazo, M.; Pesqueira Fontan, P.M.; Magallanes Gamboa, J.O.; González García, A.; Crestelo Vieitez, A.; Fonseca Aizpuru, E.M.; Aranguren Arostegui, A.; Coduras Erdozain, A.; Martinez Cilleros, C.; Loureiro Amigo, J.; Epelde, F.; Lumbreras Bermejo, C.; Antón Santos, J.M.; for the SEMI-COVID-19 Network. The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals. J. Clin. Med. 2021. doi:10.3390/jcm10020305
  22. Rodilla E, Lopez-Carmona MD, Cortes X, et al. Impact of arterial stiffness on all-cause mortality in patients hospitalized with COVID-19 in Spain. Hypertension 2020; Epub ahead of print doi: doi.org/10.1161/HYPERTENSIONAHA.120.16563
  23. Antúnez MG, Míguez AM, Estrada ADB, et al. Clinical Characteristics and Prognosis of COPD Patients Hospitalized with SARS-CoV-2. Int J Chron Obstruct Pulmon Dis 2021;15:3433–45. doi: 10.2147/COPD.S276692
  24. Bernabeu-Wittel M, Gómez-Huelgas R, Nieto-Martín MD; SEMI-COVID-19 Network. Time to Stop the Tragedy in Spanish Nursing Homes during the COVID-19 Pandemic. J Am Geriatr Soc. 2020 Nov 12. doi: 10.1111/jgs.16943. Epub ahead of print. PMID: 33179762.
  25. Luis M. Pérez-Belmonte, José David Torres-Peña, María D. López-Carmona, M. Mar. Ayala-Gutiérrez, Francisco Fuentes-Jiménez, Lucía Jorge Huerta, Jaime Alonso Muñoz, Manuel Rubio-Rivas, Manel Madrazo, Marcos Guzmán Garcia, Beatriz Vicente Montes, Joaquim Fernández Sola, Javier Ena, Ruth Gonzalez Ferrer, Carmen Mella Pérez, Carlos Jorge Ripper, Jose Javier Napal Lecumberri, Iris El Attar Acedo, Susana Plaza Canteli, Sara Fuente Cosío, Francisco Amorós Martínez, Begoña Cortés Rodríguez, Pablo Pérez-Martínez, José Manuel Ramos-Rincón, Ricardo Gómez-Huelgas, for the SEMI-COVID-19 Network. Mortality and other adverse outcomes in patients with type 2 diabetes mellitus admitted for COVID-19 in association with glucose-lowering drugs: a nationwide cohort study. BMC Med 18, 359 (2020). https://doi.org/10.1186/s12916-020-01832-2
  26. Rubio-Rivas, M.; Corbella, X.; Mora-Luján, J.M.; Loureiro-Amigo, J.; López Sampalo, A.; Yera Bergua, C.; Esteve Atiénzar, P.J.; Díez García, L.F.; Gonzalez Ferrer, R.; Plaza Canteli, S.; Pérez Piñeiro, A.; Cortés Rodríguez, B.; Jorquer Vidal, L.; Pérez Catalán, I.; León Téllez, M.; Martín Oterino, J.Á.; Martín González, M.C.; Serrano Carrillo de Albornoz, J.L.; García Sardon, E.; Alcalá Pedrajas, J.N.; Martin-Urda Diez-Canseco, A.; Esteban Giner, M.J.; Tellería Gómez, P.; Ramos-Rincón, J.M.; Gómez-Huelgas, R. Predicting Clinical Outcome with Phenotypic Clusters in COVID-19 Pneumonia: An Analysis of 12,066 Hospitalized Patients from the Spanish Registry SEMI-COVID-19J. Clin. Med. 2020, 9, 3488.
  27. Ramos-Rincon JM, Buonaiuto V, Ricci M, Martín-Carmona J, Paredes-Ruíz D, Calderón-Moreno M, Rubio-Rivas M, Beato-Pérez JL, Arnalich-Fernández F, Monge-Monge D, Vargas-Núñez JA, Acebes-Repiso G, Mendez-Bailon M, Perales-Fraile I, García-García GM, Guisado-Vasco P, Abdelhady-Kishta A, Pascual-Pérez MD, Rodríguez-Fernández-Viagas C, Montaño-Martínez A, López-Ruiz A, Gonzalez-Juarez MJ, Pérez-García C, Casas-Rojo JM, Gómez-Huelgas R; SEMI-COVID-19 Network. Clinical Characteristics and Risk Factors for Mortality in Very Old Patients Hospitalized with COVID-19 in SpainJ Gerontol A Biol Sci Med Sci. 2020 Oct 26:glaa243. doi: 10.1093/gerona/glaa243. Epub ahead of print. PMID: 33103720.
  28. Carrasco-Sánchez FJ, López-Carmona MD, Martínez-Marcos FJ, Pérez-Belmonte LM, Hidalgo-Jiménez A, Buonaiuto V, Suárez Fernández C, Freire Castro SJ, Luordo D, Pesqueira Fontan PM, Blázquez Encinar JC, Magallanes Gamboa JO, de la Peña Fernández A, Torres Peña JD, Fernández Solà J, Napal Lecumberri JJ, Amorós Martínez F, Guisado Espartero ME, Jorge Ripper C, Gómez Méndez R, Vicente López N, Román Bernal B, Rojano Rivero MG, Ramos Rincón JM, Gómez Huelgas R; SEMI-COVID-19 Network. Admission hyperglycemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: Data from the Spanish SEMI-COVID-19 Registry. Ann Med. 2020 Oct 16:1-22. doi: 10.1080/07853890.2020.1836566. Epub ahead of print. PMID: 33063540.
  29. Rodilla E, Saura A, Jiménez I, Mendizábal A, Pineda-Cantero A, Lorenzo-Hernández E, Fidalgo-Montero MDP, López-Cuervo JF, Gil-Sánchez R, Rabadán-Pejenaute E, Abella-Vázquez L, Giner-Galvañ V, Solís-Marquínez MN, Boixeda R, Peña-Fernández A, Carrasco-Sánchez FJ, González-Moraleja J, Torres-Peña JD, Guisado-Espartero ME, Escobar-Sevilla J, Guzmán-García M, Martín-Escalante MD, Martínez-González ÁL, Casas-Rojo JM, Gómez-Huelgas R. Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19J Clin Med. 2020 Sep 28;9(10):E3136. doi: 10.3390/jcm9103136. PMID: 32998337.
  30. Casas-Rojo JM, Antón-Santos JM, Millán-Núñez-Cortés J, Lumbreras-Bermejo C, Ramos-Rincón JM, Roy-Vallejo E, Artero-Mora A, Arnalich-Fernández F, García-Bruñén JM, Vargas-Núñez JA, Freire-Castro SJ, Manzano-Espinosa L, Perales-Fraile I, Crestelo-Viéitez A, Puchades-Gimeno F, Rodilla-Sala E, Solís-Marquínez MN, Bonet-Tur D, Fidalgo-Moreno MP, Fonseca-Aizpuru EM, Carrasco-Sánchez FJ, Rabadán-Pejenaute E, Rubio-Rivas M, Torres-Peña JD, Gómez-Huelgas R; en nombre del Grupo SEMI-COVID-19 Network. Clinical characteristics of patients hospitalized with COVID-19 in Spain: Results from the SEMI-COVID-19 Registry. Rev Clin Esp. 2020 Nov;220(8):480-494. English, Spanish. doi: 10.1016/j.rce.2020.07.003. Epub 2020 Jul 19. PMID: 32762922; PMCID: PMC7368900.