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Effectiveness and safety of ertapenem used in hospital-at-home units: data from Spanish Outpatient Parenteral Antimicrobial Therapy
To evaluate the effectiveness and safety of ertapenem in patients hospitalized at home.
PATIENTS & METHODS:
Retrospective analysis of data from Spanish Outpatient Parenteral Antimicrobial Therapy (OPAT) registry.
Data from 1428 patients (median age 70 years; 5.4% institutionalized) and 1547 infectious processes (24% self-administration) were analyzed. Clinical cure or improvement was achieved in 93.8% of cases. Rate of related readmissions was 4.2%, of clinically important complications -3.9%, and of adverse drug reactions -3.2%. High comorbidity burden, contagion in nursing home and certain types of infection were associated with worse prognosis. Self-administration was effective and safe, except in case of nursing home-acquired infections.
Ertapenem OPAT was effective and safe. Caregivers in nursing homes should be better trained in OPAT-related procedures.
Sanroma P, Muñoz P, Mirón-Rubio M, Aguilera A, Estrada O, García D, González Ramallo VJ, Pajarón M, Sgaramella GA, González CR, Mujal A, Abad, A, Solé A, González S, Escalada C, Vitoria I, Gómez MJ, Parra JJ, Sampedro I, Pereda I